Mosquitoes could soon be used as vaccine delivery vehicles

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Mosquitoes could soon be used as vaccine delivery vehicles

By admin, Kasım 24, 2024

Mosquitoes could soon be used as vaccine delivery vehicles





Mosquitoes could soon be used as vaccine delivery vehicles



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Researchers at the London School of Hygiene and Tropical Medicine, mosquitoes achieved a groundbreaking success in vaccine distribution using Unlike traditional methods, this innovative method is applied through mosquito bites. grafting technique, It showed up to 90% effectiveness in clinical trials. This development is particularly malaria It opens the doors to a new era in the fight against tropical diseases such as.

A new era may begin with genetic modification of the malaria parasite

The research team focused on using mosquitoes, commonly known as disease carriers, for a beneficial purpose. The study focuses on the main cause of malaria: Plasmodium falciparum contains a genetically modified version of the parasite. This modified parasite, called GA2, unlike the normal malaria parasite, does not cause disease but instead causes disease. strengthens the immune system.




Life cycle of Plasmodium falciparum, the mosquito-borne parasite that causes malaria



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Scientists applied a two-stage testing protocol in clinical trials conducted on 43 volunteers. In the first phase, 20 participants were exposed to bites from mosquitoes carrying the modified parasite, and none of the participants developed blood infections. In the second stage, 23 volunteers received mosquito bites three times, 28 days apart. from this group 89% of those vaccinated with the GA2 parasitesuccessfully protected against subsequent malaria exposure.

However, this innovative approach has some challenges to overcome before it can be put into widespread use. Transferring the parasites cultured on human blood cells in the laboratory to mosquitoes and making these mosquitoes ready as vaccine carriers takes approximately two weeks continues. This makes large-scale applications difficult.

























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