A treatment that can repair the damage caused by a heart attack has been developed

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A treatment that can repair the damage caused by a heart attack has been developed

By admin, Ocak 18, 2025

A treatment that can repair the damage caused by a heart attack has been developed





A treatment that can repair the damage caused by a heart attack has been developed



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Heart attack what happened after tissue damagecontinues to be one of the most challenging problems in modern medicine, the from the Hubrecht Institute Scientists have made a groundbreaking discovery. Researchers, zebrafish He solved the secret behind his extraordinary ability to regenerate heart tissue.

Here is the scientific journey from zebrafish to humans:

Although the scar tissue formed in patients who have a heart attack helps maintain the shape of the heart, this non-beating tissue breaks down over time. rhythm disorders and even to heart failure It can cause However zebra fishdamaged heart tissue only Within 60 days, the protein gene called Hmga1 Thanks to this, it can be completely repaired. This feature attracted the attention of scientists and opened the door to new research.

The research team tested the Hmga1 protein, which enables zebrafish to repair heart tissue, in mouse experiments. Using a viral vector, the researchers delivered this protein into damaged heart tissue of mice. As a result of the experiment, heart muscle cells began to divide and grow. Thus, significant improvements were observed in the heart functions of the mice.




A treatment that can repair the damage caused by a heart attack has been developed



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One of the most striking aspects of the study is that the treatment targeting only damaged areas. One of the authors of the study Mara Bouwman As stated, no cell division was observed in healthy heart tissue and no unwanted side effects such as overgrowth occurred. This selective effect suggests that the damage itself triggers the repair process.

Also found in humans Hmga1 strangerAlthough active during embryonic development, it shuts down shortly after birth. This discovery by reactivating a dormant gene It suggests that the damage after a heart attack can be repaired. Researchers are now preparing to examine the effect of this protein on human heart muscle cells.






Source

https://www.hubrecht.eu/zebrafish-protein-unlocks-dormant-genes-for-heart-repair/


https://www.nature.com/articles/s44161-024-00588-9






















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